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Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

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Synthesis of 18F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination

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Title
Synthesis of 18F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination
Author
Kwon, Young-DoJeon, Min HoPark, Nam KyuSeo, Jeong KonSon, JeongminRyu, Young HoonHong, Sung YouChun, Joong-Hyun
Issue Date
2020-07
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.22, no.14, pp.5511 - 5516
Abstract
Sulfuryl fluoride gas is a key reagent for SO2F transfer. However, conventional SO2F transfer reactions have limited F-18-radiochemistry translation, due to the inaccessibility of gaseous [F-18] SO2F2. Herein, we report the first SO2F2-free synthesis of aryl [F-18]fluorosulfates from both phenolic and isolated aryl imidazylate precursors with cyclotron-produced F-18(-) . The radiochemical yields ranged from moderate to good with excellent functional group tolerance. The reliability of our approach was validated by the automated radiosynthesis of 4-acetamidophenyl [F-18]fluorosulfate.
URI
https://scholarworks.unist.ac.kr/handle/201301/32383
URL
https://pubs.acs.org/doi/10.1021/acs.orglett.0c01868
DOI
10.1021/acs.orglett.0c01868
ISSN
1523-7060
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CHM_Journal Papers
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