Full metadata record
DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Lee, Ju Youn | - |
dc.contributor.author | Han, Seung Hoon | - |
dc.contributor.author | Park, Min Hee | - |
dc.contributor.author | Song, Im-Sook | - |
dc.contributor.author | Choi, Min-Koo | - |
dc.contributor.author | Yu, Eunsoo | - |
dc.contributor.author | Park, Cheol-Min | - |
dc.contributor.author | Kim, Hee-Jin | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Schuchman, Edward H. | - |
dc.contributor.author | Jin, Hee Kyung | - |
dc.contributor.author | Bae, Jae-sung | - |
dc.date.accessioned | 2023-12-21T17:38:16Z | - |
dc.date.available | 2023-12-21T17:38:16Z | - |
dc.date.created | 2020-06-05 | - |
dc.date.issued | 2020-05 | - |
dc.description.abstract | Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer's disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated by acetyl-CoA and sphingosine through SphK1. N-AS then acetylates serine 565 (S565) of COX2, and the N-AS-acetylated COX2 induces the production of specialized pro-resolving mediators (SPMs). In a mouse model of AD, microglia show a reduction in N-AS generation, leading to decreased acetyl-S565 COX2 and SPM production. Treatment with N-AS increases acetylated COX2 and N-AS-triggered SPMs in microglia of AD mice, leading to resolution of neuroinflammation, an increase in microglial phagocytosis, and improved memory. Taken together, these results identify a role of N-AS in the dysfunction of microglia in AD. Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer's disease models. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.11, no.1 | - |
dc.identifier.doi | 10.1038/s41467-020-16080-4 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-85084501724 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/32323 | - |
dc.identifier.url | https://www.nature.com/articles/s41467-020-16080-4 | - |
dc.identifier.wosid | 000537248100001 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | RESOLVING LIPID MEDIATORS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NAIVE | - |
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