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Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, Stochastic fluctuations in a cell, Biochemical information processing, Human microbiome, Ecological inference, Nonequilibrium active system

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Large-scale metabolic interaction network of the mouse and human gut microbiota

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dc.contributor.author Lim, Roktaek ko
dc.contributor.author Cabatbat, Josephine Jill T. ko
dc.contributor.author Martin, Thomas L. P. ko
dc.contributor.author Kim, Haneul ko
dc.contributor.author Kim, Seunghyeon ko
dc.contributor.author Sung, Jaeyun ko
dc.contributor.author Ghim, Cheol-Min ko
dc.contributor.author Kim, Pan-Jun ko
dc.date.available 2020-06-08T01:38:43Z -
dc.date.created 2020-06-03 ko
dc.date.issued 2020-06 ko
dc.identifier.citation SCIENTIFIC DATA, v.7, no.1, pp.204 ko
dc.identifier.issn 2052-4463 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/32319 -
dc.description.abstract The role of our gut microbiota in health and disease is largely attributed to the collective metabolic activities of the inhabitant microbes. A system-level framework of the microbial community structure, mediated through metabolite transport, would provide important insights into the complex microbe-microbe and host-microbe chemical interactions. This framework, if adaptable to both mouse and human systems, would be useful for mechanistic interpretations of the vast amounts of experimental data from gut microbiomes in murine animal models, whether humanized or not. Here, we constructed a literature-curated, interspecies network of the mammalian gut microbiota for mouse and human hosts, called NJC19. This network is an extensive data resource, encompassing 838 microbial species (766 bacteria, 53 archaea, and 19 eukaryotes) and 6 host cell types, interacting through 8,224 small-molecule transport and macromolecule degradation events. Moreover, we compiled 912 negative associations between organisms and metabolic compounds that are not transportable or degradable by those organisms. Our network may facilitate experimental and computational endeavors for the mechanistic investigations of host-associated microbial communities. ko
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title Large-scale metabolic interaction network of the mouse and human gut microbiota ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85086830733 ko
dc.identifier.wosid 000545966200001 ko
dc.type.rims ART ko
dc.identifier.doi 10.1038/s41597-020-0516-5 ko
dc.identifier.url https://www.nature.com/articles/s41597-020-0516-5 ko
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