The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission

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dc.contributor.author Kim, Ji-hyung ko
dc.contributor.author Ki, Yoonhee ko
dc.contributor.author Lee, Hoyeon ko
dc.contributor.author Hur, Moon Seong ko
dc.contributor.author Baik, Bukyung ko
dc.contributor.author Hur, Jin-Hoe ko
dc.contributor.author Nam, Dougu ko
dc.contributor.author Lim, Chunghun ko
dc.date.available 2020-04-23T10:15:14Z -
dc.date.created 2020-04-17 ko
dc.date.issued 2020-04 ko
dc.identifier.citation COMMUNICATIONS BIOLOGY, v.3, no.1, pp.174 ko
dc.identifier.issn 2399-3642 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/31988 -
dc.description.abstract Genes and neural circuits coordinately regulate animal sleep. However, it remains elusive how these endogenous factors shape sleep upon environmental changes. Here, we demonstrate that Shaker (Sh)-expressing GABAergic neurons projecting onto dorsal fan-shaped body (dFSB) regulate temperature-adaptive sleep behaviors in Drosophila. Loss of Sh function suppressed sleep at low temperature whereas light and high temperature cooperatively gated Sh effects on sleep. Sh depletion in GABAergic neurons partially phenocopied Sh mutants. Furthermore, the ionotropic GABA receptor, Resistant to dieldrin (Rdl), in dFSB neurons acted downstream of Sh and antagonized its sleep-promoting effects. In fact, Rdl inhibited the intracellular cAMP signaling of constitutively active dopaminergic synapses onto dFSB at low temperature. High temperature silenced GABAergic synapses onto dFSB, thereby potentiating the wake-promoting dopamine transmission. We propose that temperature-dependent switching between these two synaptic transmission modalities may adaptively tune the neural property of dFSB neurons to temperature shifts and reorganize sleep architecture for animal fitness. Ji-hyung Kim and Yoonhee Ki et al. show that low temperatures suppress sleep in Drosophila by increasing GABA transmission in Shaker-expressing GABAergic neurons projecting onto the dorsal fan-shaped body, while high temperatures potentiate dopamine-induced arousal by reducing GABA transmission. This study highlights a role for Shaker in sleep modulation via a temperature-dependent switch in GABA signaling. ko
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85083478343 ko
dc.identifier.wosid 000528742400002 ko
dc.type.rims ART ko
dc.identifier.doi 10.1038/s42003-020-0902-8 ko
dc.identifier.url https://www.nature.com/articles/s42003-020-0902-8 ko
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