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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 603 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 593 | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Datta, A | - |
dc.contributor.author | Schmeits, JL | - |
dc.contributor.author | Amin, NS | - |
dc.contributor.author | Lau, PJ | - |
dc.contributor.author | Myung, K | - |
dc.contributor.author | Kolodner, RD | - |
dc.date.accessioned | 2023-12-22T12:06:49Z | - |
dc.date.available | 2023-12-22T12:06:49Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2000-09 | - |
dc.description.abstract | The Saccharomyces cerevisiae DNA polymerase delta proofreading exonuclease-defective mutation pol3-01 is known to cause high rates of accumulating mutations. The pol3-01 mutant was found to have abnormal cell cycle progression due to activation of the S phase checkpoint. Inactivation of the S phase checkpoint suppressed both the pol3-01 cell cycle progression defect and mutator phenotype, indicating that the pol3-01 mutator phenotype was dependent on the S phase damage checkpoint pathway. Epistasis analysis suggested that a portion of the pol3-01 mutator phenotype involves members of the RAD6 epistasis group that function in both error-free and error-prone repair. These results indicate that activation of a checkpoint in response to certain types of replicative defects can result in the accumulation of mutations. | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.6, no.3, pp.593 - 603 | - |
dc.identifier.doi | 10.1016/S1097-2765(00)00058-7 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.scopusid | 2-s2.0-0033636253 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31097 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1097276500000587?via%3Dihub | - |
dc.identifier.wosid | 000089578600009 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DNA MISMATCH REPAIR | - |
dc.subject.keywordPlus | BACTERIOPHAGE-T7 DEOXYRIBONUCLEIC-ACID | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCISION-REPAIR | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI DINB | - |
dc.subject.keywordPlus | CELL NUCLEAR ANTIGEN | - |
dc.subject.keywordPlus | STRAND-BREAK REPAIR | - |
dc.subject.keywordPlus | MUTATION AVOIDANCE | - |
dc.subject.keywordPlus | POLYMERASE-DELTA | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CHROMOSOMAL REARRANGEMENTS | - |
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