There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 26575 | - |
dc.citation.number | 32 | - |
dc.citation.startPage | 26563 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 287 | - |
dc.contributor.author | Daee, Danielle L. | - |
dc.contributor.author | Ferrari, Elisa | - |
dc.contributor.author | Longerich, Simonne | - |
dc.contributor.author | Zheng, Xiao-feng | - |
dc.contributor.author | Xue, Xiaoyu | - |
dc.contributor.author | Branzei, Dana | - |
dc.contributor.author | Sung, Patrick | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2023-12-22T04:45:28Z | - |
dc.date.available | 2023-12-22T04:45:28Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2012-08 | - |
dc.description.abstract | Interstrand cross-links (ICLs) covalently link complementary DNA strands, block DNA replication, and transcription and must be removed to allow cell survival. Several pathways, including the Fanconi anemia (FA) pathway, can faithfully repair ICLs and maintain genomic integrity; however, the precise mechanisms of most ICL repair processes remain enigmatic. In this study we genetically characterized a conserved yeast ICL repair pathway composed of the yeast homologs (Mph1, Chl1, Mhf1, Mhf2) of four FA proteins (FANCM, FANCJ, MHF1, MHF2). This pathway is epistatic with Rad5-mediated DNA damage bypass and distinct from the ICL repair pathways mediated by Rad18 and Pso2. In addition, consistent with the FANCM role in stabilizing ICL-stalled replication forks, we present evidence that Mph1 prevents ICL-stalled replication forks from collapsing into double-strand breaks. This unique repair function of Mph1 is specific for ICL damage and does not extend to other types of damage. These studies reveal the functional conservation of the FA pathway and validate the yeast model for future studies to further elucidate the mechanism of the FA pathway. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.287, no.32, pp.26563 - 26575 | - |
dc.identifier.doi | 10.1074/jbc.M112.369918 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-84864556570 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31038 | - |
dc.identifier.url | https://www.jbc.org/content/287/32/26563 | - |
dc.identifier.wosid | 000307386000009 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Rad5-dependent DNA Repair Functions of the Saccharomyces cerevisiae FANCM Protein Homolog Mph1 | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INTERSTRAND CROSS-LINKS | - |
dc.subject.keywordPlus | CELL NUCLEAR ANTIGEN | - |
dc.subject.keywordPlus | FREE POSTREPLICATION REPAIR | - |
dc.subject.keywordPlus | STALLED REPLICATION FORKS | - |
dc.subject.keywordPlus | STRAND BREAK REPAIR | - |
dc.subject.keywordPlus | GROSS CHROMOSOMAL REARRANGEMENTS | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCISION-REPAIR | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | RAD6 PATHWAY | - |
dc.subject.keywordPlus | ERROR-PRONE | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.