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DC Field | Value | Language |
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dc.citation.endPage | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | CURRENT BIOLOGY | - |
dc.citation.volume | 14 | - |
dc.contributor.author | Boulton, SJ | - |
dc.contributor.author | Martin, JS | - |
dc.contributor.author | Polanowska, J | - |
dc.contributor.author | Hill, DE | - |
dc.contributor.author | Gartner, A | - |
dc.contributor.author | Vidal, M | - |
dc.date.accessioned | 2023-12-22T11:07:08Z | - |
dc.date.available | 2023-12-22T11:07:08Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2004-01 | - |
dc.description.abstract | Inherited germline mutations in the tumor suppressor gene BRCA1 predispose individuals to early onset breast and ovarian cancer [1]. BRCA1 together with its structurally related partner BARD1 is required for homologous recombination and DNA double-strand break repair, but how they perform these functions remains elusive [2, 3]. As part of a comprehensive search for DNA repair genes in C. elegans, we identified a BARD1 ortholog. In protein interaction screens, Ce-BRD-1 was found to interact with components of the sumoylation pathway, the TACC domain protein TAC-1, and most importantly, a homolog of mammalian BRCA1. We show that animals depleted for either Ce-brc-1 or Ce-brd-1 display similar abnormalities, including a high incidence of males, elevated levels of p53-dependent germ cell death before and after irradiation, and impaired progeny survival and chromosome fragmentation after irradiation. Furthermore, depletion of ubc-9 and tac-1 leads to radiation sensitivity and a high incidence of males, respectively, potentially linking these genes to the C. elegans BRCA1 pathway. Our findings support a shared role for Ce-BRC-1 and Ce-BRD-1 in C. elegans DNA repair processes, and this role will permit studies of the BRCA1 pathway in an organism amenable to rapid genetic and biochemical analysis. | - |
dc.identifier.bibliographicCitation | CURRENT BIOLOGY, v.14, no.1, pp.33 - 39 | - |
dc.identifier.doi | 10.1016/j.cub.2003.11.029 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.scopusid | 2-s2.0-0346335800 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31019 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960982203008716?via%3Dihub | - |
dc.identifier.wosid | 000188118500021 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | DAMAGE RESPONSE | - |
dc.subject.keywordPlus | MEIOTIC CELLS | - |
dc.subject.keywordPlus | BRCA1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | LIGASE | - |
dc.subject.keywordPlus | BARD1 | - |
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