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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 429 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 421 | - |
dc.citation.title | MECHANISMS OF AGEING AND DEVELOPMENT | - |
dc.citation.volume | 126 | - |
dc.contributor.author | Leroi, AM | - |
dc.contributor.author | Bartke, A | - |
dc.contributor.author | De Benedictis, G | - |
dc.contributor.author | Franceschi, C | - |
dc.contributor.author | Gartner, A | - |
dc.contributor.author | Gonos, E | - |
dc.contributor.author | Feder, ME | - |
dc.contributor.author | Kivisild, T | - |
dc.contributor.author | Lee, S | - |
dc.contributor.author | Kartal-Ozer, N | - |
dc.contributor.author | Schumacher, M | - |
dc.contributor.author | Sikora, E | - |
dc.contributor.author | Slagboom, E | - |
dc.contributor.author | Tatar, M | - |
dc.contributor.author | Yashin, AI | - |
dc.contributor.author | Vijg, J | - |
dc.contributor.author | Zwaan, B | - |
dc.date.accessioned | 2023-12-22T10:37:31Z | - |
dc.date.available | 2023-12-22T10:37:31Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2005-03 | - |
dc.description.abstract | Classical evolutionary theory predicts the existence of genes with antagonistic effects on longevity and various components of early-life fitness. Quantitative genetic studies have provided convincing evidence that such genes exist. However, antagonistic pleiotropic effects have rarely been attributed to individual loci. We examine several classes of longevity-assurance genes: those involved in regulation of the gonad; the insulin-like growth factor pathway; free-radical scavenging; heat shock proteins and apoptosis. We find initial evidence that antagonistic pleiotropic effects are pervasive in each of these classes of genes and in various model systems-although most studies lack explicit studies of fitness components. This is particularly true of human studies. Very little is known about the early-life fitness effects of longevity loci. Given the possible medical importance of such effects we urge their future study. | - |
dc.identifier.bibliographicCitation | MECHANISMS OF AGEING AND DEVELOPMENT, v.126, no.3, pp.421 - 429 | - |
dc.identifier.doi | 10.1016/j.mad.2004.07.012 | - |
dc.identifier.issn | 0047-6374 | - |
dc.identifier.scopusid | 2-s2.0-19944432549 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31015 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0047637404001897?via%3Dihub | - |
dc.identifier.wosid | 000226945100008 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology; Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Cell Biology; Geriatrics & Gerontology | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | NATURAL-SELECTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REPLICATIVE SENESCENCE | - |
dc.subject.keywordPlus | MOLECULAR SIGNALS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | DWARF MICE | - |
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