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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 197 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 187 | - |
dc.citation.title | PLOS GENETICS | - |
dc.citation.volume | 2 | - |
dc.contributor.author | Meier, Bettina | - |
dc.contributor.author | Clejan, Iuval | - |
dc.contributor.author | Liu, Yan | - |
dc.contributor.author | Lowden, Mia | - |
dc.contributor.author | Gartner, Anton | - |
dc.contributor.author | Hodgkin, Jonathan | - |
dc.contributor.author | Ahmed, Shawn | - |
dc.date.accessioned | 2023-12-22T10:08:02Z | - |
dc.date.available | 2023-12-22T10:08:02Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2006-02 | - |
dc.description.abstract | Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, late-generation trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere replication pathway as mrt-2, a component of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen - like sliding clamp. Thus, the 9 - 1 - 1 complex may be required for telomerase to act at chromosome ends in C. elegans. Although telomere erosion limits replicative life span in human somatic cells, neither trt-1 nor telomere shortening affects postmitotic aging in C. elegans. These findings illustrate effects of telomere dysfunction in C. elegans mutants lacking the catalytic subunit of telomerase, trt-1. | - |
dc.identifier.bibliographicCitation | PLOS GENETICS, v.2, no.2, pp.187 - 197 | - |
dc.identifier.doi | 10.1371/journal.pgen.0020018 | - |
dc.identifier.issn | 1553-7404 | - |
dc.identifier.scopusid | 2-s2.0-33645512251 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31014 | - |
dc.identifier.url | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0020018 | - |
dc.identifier.wosid | 000239494300010 | - |
dc.language | 영어 | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | FUNCTIONAL MULTIMERIZATION | - |
dc.subject.keywordPlus | LENGTH MAINTENANCE | - |
dc.subject.keywordPlus | CHECKPOINT PROTEIN | - |
dc.subject.keywordPlus | TERMINAL DOMAINS | - |
dc.subject.keywordPlus | FISSION YEAST | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | KU | - |
dc.subject.keywordPlus | PATHWAY | - |
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