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DC Field | Value | Language |
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dc.citation.endPage | 153 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 145 | - |
dc.citation.title | FUTURE ONCOLOGY | - |
dc.citation.volume | 2 | - |
dc.contributor.author | Schumacher, Björn | - |
dc.contributor.author | Gartner, Anton | - |
dc.date.accessioned | 2023-12-22T10:08:02Z | - |
dc.date.available | 2023-12-22T10:08:02Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2006-02 | - |
dc.description.abstract | The tumor suppressor p53 is a central player in apoptosis induction in response to oncogenic stimuli and DNA damage. As activation of p53 has been suggested as a prime strategy for future tumor therapy, inhibition of negative regulators of p53 activity would be a similarly desirable strategy. The small worm Caenorhabditis elegans is a model organism in which many conserved biological pathways, including the core apoptotic machinery, were elucidated. The discovery of a worm p53 homolog cep-1/p53 (which stands for C. elegans p53) that specifically induces apoptosis upon DNA damage through a pathway that is conserved from worm to man opened the way for the use of C. elegans genetics to uncover regulatory mechanisms – and hence novel therapeutic targets – of p53-mediated apoptosis. The authors have recently reported a novel mechanism of C. eleganscep-1/p53 regulation through germ line defective-1-mediated translational repression. This review discusses the potential of the worm system to screen for apoptosis-inducing cancer drugs and to identify novel p53 regulators whose human counterparts might become potential tumor therapy targets. | - |
dc.identifier.bibliographicCitation | FUTURE ONCOLOGY, v.2, no.1, pp.145 - 153 | - |
dc.identifier.doi | 10.2217/14796694.2.1.145 | - |
dc.identifier.issn | 1479-6694 | - |
dc.identifier.scopusid | 2-s2.0-33646783681 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31013 | - |
dc.identifier.url | https://www.futuremedicine.com/doi/10.2217/14796694.2.1.145 | - |
dc.language | 영어 | - |
dc.publisher | Future Medicine Ltd | - |
dc.title | Translational regulation of p53 as a potential tumor therapy target | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | apoptosisCaenorhabditis elegansDNA damageGLD-1p53translational regulation | - |
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