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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 96 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 85 | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 44 | - |
dc.contributor.author | Franz, Andre | - |
dc.contributor.author | Orth, Michael | - |
dc.contributor.author | Pirson, Paul A. | - |
dc.contributor.author | Sonneville, Remi | - |
dc.contributor.author | Blow, J. Julian | - |
dc.contributor.author | Gartner, Anton | - |
dc.contributor.author | Stemmann, Olaf | - |
dc.contributor.author | Hoppe, Thorsten | - |
dc.date.accessioned | 2023-12-22T05:42:35Z | - |
dc.date.available | 2023-12-22T05:42:35Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2011-10 | - |
dc.description.abstract | Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. In the licensing step of DNA replication, CDT-1 is loaded onto chromatin to subsequently promote the recruitment of additional replication factors, including CDC-45 and GINS. During the elongation step, the CDC-45/GINS complex moves with the replication fork; however, it is largely unknown how its chromatin association is regulated. Here, we show that the chaperone-like ATPase CDC-48/p97 coordinates degradation of CDT-1 with release of the CDC-45/GINS complex. C. elegans embryos lacking CDC-48 or its cofactors UFD-1/NPL-4 accumulate CDT-1 on mitotic chromatin, indicating a critical role of CDC-48 in CDT-1 turnover. Strikingly, CDC-48(UFD-1/NPL-4)-deficient embryos show persistent chromatin association of CDC-45/GINS, which is a consequence of CDT-1 stabilization. Moreover, our data confirmed a similar regulation in Xenopus egg extracts, emphasizing a conserved coordination of licensing and elongation events during eukaryotic DNA replication by CDC-48/p97. | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.44, no.1, pp.85 - 96 | - |
dc.identifier.doi | 10.1016/j.molcel.2011.08.028 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.scopusid | 2-s2.0-80053606383 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30994 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1097276511006873?via%3Dihub | - |
dc.identifier.wosid | 000295771200012 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | XENOPUS EGG EXTRACTS | - |
dc.subject.keywordPlus | UBIQUITIN-SELECTIVE CHAPERONE | - |
dc.subject.keywordPlus | AAA ATPASE CDC48/P97 | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | S-PHASE | - |
dc.subject.keywordPlus | PROTEIN-DEGRADATION | - |
dc.subject.keywordPlus | GENOME STABILITY | - |
dc.subject.keywordPlus | CDC45 | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
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