There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 352 | - |
dc.citation.startPage | 321 | - |
dc.citation.title | CAENORHABDITIS ELEGANS: CELL BIOLOGY AND PHYSIOLOGY, SECOND EDITION | - |
dc.citation.volume | 107 | - |
dc.contributor.author | Craig, Ashley L. | - |
dc.contributor.author | Moser, Sandra C. | - |
dc.contributor.author | Bailly, Aymeric P. | - |
dc.contributor.author | Gartner, Anton | - |
dc.date.accessioned | 2023-12-22T04:36:19Z | - |
dc.date.available | 2023-12-22T04:36:19Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2012-20 | - |
dc.description.abstract | In response to genotoxic insults, cells activate DNA damage response pathways that either stimulate transient cell cycle arrest and DNA repair or induce apoptosis. The Caenorhabditis elegans germ line is now well established as a model system to study these processes in a genetically tractable, multicellular organism. Upon treatment with genotoxic agents, premeiotic C. elegans germ cells transiently halt cell cycle progression, whereas meiotic prophase germ cells in the late-pachytene stage undergo apoptosis. Further, accumulation of unrepaired meiotic recombination intermediates can also lead to apoptosis of affected pachytene cells. DNA damage-induced cell death requires key components of the evolutionarily conserved apoptotic machinery. Moreover, both cell cycle arrest and pachytene apoptosis responses depend on conserved DNA damage checkpoint proteins. Genetics- and genomics-based approaches that have demonstrated roles for conserved checkpoint proteins have also begun to uncover novel components of these response pathways. In this chapter, we briefly review the C. elegans DNA damage response field, discuss in detail methods currently used to assay DNA damage responses in C. elegans, and describe the development of new experimental tools that will facilitate a more comprehensive understanding of the DNA damage response. | - |
dc.identifier.bibliographicCitation | CAENORHABDITIS ELEGANS: CELL BIOLOGY AND PHYSIOLOGY, SECOND EDITION, v.107, pp.321 - 352 | - |
dc.identifier.doi | 10.1016/B978-0-12-394620-1.00011-4 | - |
dc.identifier.issn | 0091-679X | - |
dc.identifier.scopusid | 2-s2.0-84855471671 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30988 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/B9780123946201000114?via%3Dihub | - |
dc.identifier.wosid | 000299611000011 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER ACADEMIC PRESS INC | - |
dc.title | Methods for Studying the DNA Damage Response in the Caenorhabdatis elegans Germ Line | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Review; Book Chapter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PROGRAMMED CELL-DEATH | - |
dc.subject.keywordPlus | CHECKPOINT PROTEIN | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | MEIOTIC PROPHASE | - |
dc.subject.keywordPlus | CROSSING-OVER | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | STRESS | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.