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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 760 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 747 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 73 | - |
dc.contributor.author | PETER, M | - |
dc.contributor.author | GARTNER, A | - |
dc.contributor.author | HORECKA, J | - |
dc.contributor.author | AMMERER, G | - |
dc.contributor.author | HERSKOWITZ, I | - |
dc.date.accessioned | 2023-12-22T13:06:31Z | - |
dc.date.available | 2023-12-22T13:06:31Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 1993-05 | - |
dc.description.abstract | Alpha factor induces arrest of yeast a cells in G1 and transcription of genes involved in mating. Prior work indicates that FUS3, a member of the MAP kinase family, and FAR1, whose molecular activity is unknown, contribute to cell cycle arrest by inhibiting G1 cyclins. Here we show that FAR1 is a substrate for FUS3 and that this phosphorylation regulates association of FAR1 with CDC28-CLN2 kinase. We show also that FAR1 is phosphorylated in vitro by the CDC28-CLN2 complex and in vivo in a CDC28-dependent manner. Mutational analysis of FAR1 reveals a correlation between its ability to associate with CDC28-CLN2 and to arrest the cell cycle. These results suggest that FAR1 protein is the link between the signaling pathway and the cell cycle machinery. | - |
dc.identifier.bibliographicCitation | CELL, v.73, no.4, pp.747 - 760 | - |
dc.identifier.doi | 10.1016/0092-8674(93)90254-N | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-0027191189 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30928 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/009286749390254N?via%3Dihub | - |
dc.identifier.wosid | A1993LD83000013 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | FAR1 LINKS THE SIGNAL-TRANSDUCTION PATHWAY TO THE CELL-CYCLE MACHINERY IN YEAST | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | POSITIVE FEEDBACK | - |
dc.subject.keywordPlus | MATING-PHEROMONE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | START | - |
dc.subject.keywordPlus | STE12 | - |
dc.subject.keywordPlus | DIVISION | - |
dc.subject.keywordPlus | ARREST | - |
dc.subject.keywordPlus | CLN2 | - |
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