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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 6 | - |
dc.citation.title | CHROMOSOMA | - |
dc.citation.volume | 112 | - |
dc.contributor.author | Alpi, A | - |
dc.contributor.author | Pasierbek, P | - |
dc.contributor.author | Gartner, A | - |
dc.contributor.author | Loidl, J | - |
dc.date.accessioned | 2023-12-22T11:10:39Z | - |
dc.date.available | 2023-12-22T11:10:39Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2003-07 | - |
dc.description.abstract | We investigated the role of Caenorhabditis elegans rad-51 during meiotic prophase. We showed that rad-51 mutant worms are viable, have no defects in meiotic homology recognition and synapsis but exhibit abnormal chromosomal morphology and univalent formation at diakinesis. During meiosis RAD-51 becomes localized to distinct foci in nuclei of the transition zone of the gonad and is most abundant in nuclei at late zygotene/early pachytene. Foci then gradually disappear from chromosomes and no foci are observed in late pachytene. RAD-51 localization requires the recombination genes spo-11 and mre-11 as well as chk-2, which is necessary for homology recognition and presynaptic alignment. Mutational analysis with synapsis- and recombination-defective strains, as well as the analysis of strains bearing heterozygous translocation chromosomes, suggests that presynaptic alignment may be required for RAD-51 focus formation, whereas homologous synaptonemal complex formation is required to remove RAD-51 foci. | - |
dc.identifier.bibliographicCitation | CHROMOSOMA, v.112, no.1, pp.6 - 16 | - |
dc.identifier.doi | 10.1007/s00412-003-0237-5 | - |
dc.identifier.issn | 0009-5915 | - |
dc.identifier.scopusid | 2-s2.0-0042566182 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30918 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00412-003-0237-5 | - |
dc.identifier.wosid | 000184326000002 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER-VERLAG | - |
dc.title | Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Genetics & Heredity | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Genetics & Heredity | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DOUBLE-STRAND BREAKS | - |
dc.subject.keywordPlus | MEIOTIC CHROMOSOME SYNAPSIS | - |
dc.subject.keywordPlus | DAMAGE-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | SYNAPTONEMAL COMPLEXES | - |
dc.subject.keywordPlus | MOUSE SPERMATOCYTES | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | RAD51 PROTEIN | - |
dc.subject.keywordPlus | DNA | - |
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