Decellularized extracellular matrix-based bio-ink with enhanced 3D printability and mechanical properties

DC Field Value Language Kim, Min Kyeong ko Jeong, Wonwoo ko Lee, Sang Min ko Kim, Jeong Beom ko Jin, Songwan ko Kang, Hyun-Wook ko 2020-01-09T10:00:39Z - 2020-01-07 ko 2020-04 ko
dc.identifier.citation BIOFABRICATION, v.12, no.2, pp.025003 ko
dc.identifier.issn 1758-5082 ko
dc.identifier.uri -
dc.description.abstract Recently, decellularized extracellular matrix-based bio-ink (dECM bio-ink) derived from animal organs is attracting attention because of its excellent biocompatibility. However, its poor 3D printability and weak mechanical properties remain a challenge. Here, we developed a new dECM bio-ink with enhanced 3D printability and mechanical properties. dECM micro-particles of about 13.4 μm in size were prepared by decellularizing a porcine liver followed by freeze-milling. The new bio-ink, named as dECM powder-based bio-ink (dECM pBio-ink), was prepared by loading the dECM micro-particles into a gelatin mixture. The usefulness of the dECM pBio-ink was evaluated by assessing its mechanical properties, printability, and cytocompatibility. The results showed that its mechanical properties and 3D printability were greatly improved. Its elastic modulus increased by up to 9.17 times that of the conventional dECM bio-ink. Micro-patterns with living cells were successfully achieved with 93 % cell viability. Above all, the new bio-ink showed superior performance in stacking of layers for 3D printing, whereas the conventional bio-ink could not maintain its shape. Finally, we demonstrated that the dECM pBio-ink possessed comparable cytocompatibility with the conventional dECM bio-ink through in-vitro tests with endothelial cells and primary mouse hepatocytes. ko
dc.language 영어 ko
dc.publisher IOP PUBLISHING LTD ko
dc.title Decellularized extracellular matrix-based bio-ink with enhanced 3D printability and mechanical properties ko
dc.type ARTICLE ko
dc.identifier.wosid 000510708700001 ko
dc.type.rims ART ko
dc.identifier.doi 10.1088/1758-5090/ab5d80 ko
dc.identifier.url ko
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