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Jeong, Hoon Eui
Multiscale Biomimetics & Manufacturing Lab
Research Interests
  • Biomimetics

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Graphene-Layered Eggshell Membrane as a Flexible and Functional Scaffold for Enhanced Proliferation and Differentiation of Stem Cells

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Title
Graphene-Layered Eggshell Membrane as a Flexible and Functional Scaffold for Enhanced Proliferation and Differentiation of Stem Cells
Author
Park, SunhoKim, TeayeopGwon, YonghyunKim, SujinKim, DaunPark, Hyun-HaLim, Ki-TaekJeong, Hoon EuiKim, KyunghoonKim, Jangho
Issue Date
2019-10
Publisher
American Chemical Society
Citation
ACS APPLIED BIO MATERIALS, v.2, no.10, pp.4242 - 4248
Abstract
The eggshell membrane (ESM) is usually regarded as an agricultural byproduct waste, even though it has unique properties as a biomaterial. In particular, the ESM has a flexible and highly pure microfibrous network structure that can be used as an artificial extracellular matrix (ECM) platform for engraftment or as a tissue-engineered scaffold. In this study, flexible and functional scaffolds were constructed using an ESM and graphene, and their applicability for stem cell and tissue engineering was analyzed. The graphene-layered ESM (GEM) scaffolds show enhanced characteristics, such as ECM-like hierarchical micro- and nanostructures and better mechanical and hydrophilic properties than those of a raw ESM. The GEM scaffolds can control the adhesion properties of stem cells, enhancing the proliferation and osteogenic properties of the cells compared with the effects of a raw ESM. Additionally, the GEM scaffolds can improve the secretion of growth factors from stem cells, possibly through enhanced cell–substrate interactions, thereby promoting the proliferation and differentiation of these cells.
URI
https://scholarworks.unist.ac.kr/handle/201301/30463
URL
https://pubs.acs.org/doi/10.1021/acsabm.9b00525
DOI
10.1021/acsabm.9b00525
ISSN
2576-6422
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