There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 3226 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 3215 | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 79 | - |
dc.contributor.author | Seo, Jae Ho | - |
dc.contributor.author | Chae, Young Chan | - |
dc.contributor.author | Kossenkov, Andrew V | - |
dc.contributor.author | Lee, Yu Geon | - |
dc.contributor.author | Tang, Hsin-Yao | - |
dc.contributor.author | Agarwal, Ekta | - |
dc.contributor.author | Gabrilovich, Dmitry I | - |
dc.contributor.author | Languino, Lucia R. | - |
dc.contributor.author | Speicher, David W. | - |
dc.contributor.author | Shastrula, Prashanth K. | - |
dc.contributor.author | Storaci, Alessandra Maria | - |
dc.contributor.author | Ferrero, Stefano | - |
dc.contributor.author | Gaudioso, Gabriella | - |
dc.contributor.author | Caroli, Manuela | - |
dc.contributor.author | Tosi, Davide | - |
dc.contributor.author | Giroda, Massimo | - |
dc.contributor.author | Vaira, Valentina | - |
dc.contributor.author | Rebecca, Vito W | - |
dc.contributor.author | Herlyn, Meenhard | - |
dc.contributor.author | Xiao, Min | - |
dc.contributor.author | Fingerman, Dylan | - |
dc.contributor.author | Martorella, Alessandra | - |
dc.contributor.author | Skordalakes, Emmanuel | - |
dc.contributor.author | Altieri, Dario C. | - |
dc.date.accessioned | 2023-12-21T18:16:09Z | - |
dc.date.available | 2023-12-21T18:16:09Z | - |
dc.date.created | 2019-11-12 | - |
dc.date.issued | 2019-12 | - |
dc.description.abstract | The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of Mitochondrial Fission Factor (MFF1 and MFF2), a molecule that controls mitochondrial size and shape, i.e. mitochondrial dynamics, were overexpressed in patients with non-small cell lung cancer and formed homo- and heterodimeric complexes with the voltage-dependent anion channel-1 (VDAC1), a key regulator of mitochondrial outer membrane permeability. MFF inserted into the interior hole of the VDAC1 ring using Arg225, Arg236 and Gln241 as key contact sites. A cell-permeable MFF Ser223-Leu243 D-enantiomeric peptidomimetic disrupted the MFF-VDAC1 complex, acutely depolarized mitochondria and triggered cell death in heterogeneous tumor types, including drug-resistant melanoma, but had no effect on normal cells. In preclinical models, treatment with the MFF peptidomimetic was well-tolerated and demonstrated anticancer activity in patient-derived xenografts, primary breast and lung adenocarcinoma 3D organoids and glioblastoma neurospheres. These data identify the MFF-VDAC1 complex as a novel regulator of mitochondrial cell death and an actionable therapeutic target in cancer. | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.79, no.24, pp.3215 - 3226 | - |
dc.identifier.doi | 10.1158/0008-5472.can-19-1982 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.scopusid | 2-s2.0-85076445310 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30342 | - |
dc.identifier.url | https://cancerres.aacrjournals.org/content/79/24/6215 | - |
dc.identifier.wosid | 000502957200016 | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | MFF REGULATION OF MITOCHONDRIAL CELL DEATH IS A THERAPEUTIC TARGET IN CANCER | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DOCK WEB SERVER | - |
dc.subject.keywordPlus | PERMEABILITY TRANSITION | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | VDAC | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NECROSIS | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.