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Do, Yoonkyung
DC-based Immune System & Immunotherapy (DISNI) Lab
Research Interests
  • Study on various subsets of dendritic cells and their immunological functions

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Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

Cited 17 times inthomson ciCited 14 times inthomson ci
Title
Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration
Author
Ryu, SeonghoMcDonnell, KevinChoi, HyejinGao, DingchengHahn, MaryJoshi, NatashaPark, Sun-MiCatena, RaulDo, YoonkyungBrazin, JacquelineVandat, Linda T.Silver, Randi B.Mittal, Vivek
Keywords
BREAST-CANCER METASTASIS; FOCAL ADHESION KINASE; ENDOTHELIAL PROGENITOR CELLS; EMBRYONIC STEM-CELLS; MICRORNA EXPRESSION; TUMOR-METASTASIS; PROSTATE-CANCER; MESENCHYMAL TRANSITION; INTRACELLULAR CALCIUM; FAK PHOSPHORYLATION
Issue Date
2013-01
Publisher
CELL PRESS
Citation
CANCER CELL, v.23, no.1, pp.63 - 76
Abstract
The progression of cancer to metastatic disease is a major cause of death. We identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer. miR-708 targets the endoplasnnic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Ectopic expression of neuronatin refractory to suppression by miR-708 rescued cell migration and metastasis defects. In patients with breast cancer, miR-708 expression was decreased in lymph node and distal metastases, suggesting a metastasis-suppressive role. Our findings uncover a mechanistic role for miR-708 in metastasis and provide a rationale for developing nniR-708 as a therapeutic agent against metastatic breast cancer.
URI
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DOI
10.1016/j.ccr.2012.11.019
ISSN
1535-6108
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SLS_Journal Papers
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