DNA Hybridization Sensors Based on Electrochemical Impedance Spectroscopy as a Detection Tool
Cited 48 times inCited 47 times in
- DNA Hybridization Sensors Based on Electrochemical Impedance Spectroscopy as a Detection Tool
- Park, Jin-Young; Park, Su-Moon
- Conducting polymers; DNA; EIS; Nanostructures; Self-assembled monolayers
- Issue Date
- MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
- SENSORS, v.9, no.12, pp.9513 - 9532
- Recent advances in label free DNA hybridization sensors employing electrochemical impedance spectroscopy ( EIS) as a detection tool are reviewed. These sensors are based on the modulation of the blocking ability of an electrode modified with a probe DNA by an analyte, i.e., target DNA. The probe DNA is immobilized on a self-assembled monolayer, a conducting polymer film, or a layer of nanostructures on the electrode such that desired probe DNA would selectively hybridize with target DNA. The rate of charge transfer from the electrode thus modified to a redox indicator, e. g., [Fe(CN)(6)](3-/4-), which is measured by EIS in the form of charge transfer resistance (R(ct)), is modulated by whether or not, as well as how much, the intended target DNA is selectively hybridized. Efforts made to enhance the selectivity as well as the sensitivity of DNA sensors and to reduce the EIS measurement time are briefly described along with brief future perspectives in developing DNA sensors.
- ; Go to Link
- Appears in Collections:
- PHY_Journal Papers
- Files in This Item:
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.