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Park, Tae-Eun
Microtissue Engineering & Nanomedicine Lab
Research Interests
  • Drug delivery, Drug development, Tissue Engineering, Organ-on-a-chip, Stem Cell Engineering, Cell Biology, 3D printing for tissue engineering, Neurobiology, Nano Biotechnology

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Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior

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Title
Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior
Author
Park, SunhoPark, Hyun-HaSun, KahyunGwon, YonghyunSeong, MinhoKim, SujinPark, Tae-EunHyun, HoonChoung, Yun-HoonKim, JanghoJeong, Hoon Eui
Issue Date
2019-10
Publisher
American Chemical Society
Citation
ACS NANO, v.13, no.10, pp.11181 - 11193
Abstract
Vertically aligned nanomaterials, such as nanowires and nanoneedles, hold strong potential as efficient platforms onto which living cells or tissues can be interfaced for use in advanced biomedical applications. However, their rigid mechanical properties and complex fabrication processes hinder their integration onto flexible, tissue-adaptable, and large-area patch-type scaffolds, limiting their practical applications. In this study, we present a highly flexible patch that possesses a spiky hydrogel nanostructure array as a transplantable platform for enhancing the growth and differentiation of stem cells and efficiently suppressing biofilm formation. In vitro studies show that the hydrogel nanospike patch imposes a strong physical stimulus to the membranes of stem cells and enhances their osteogenic, chondrogenic, and adipogenic differentiation and the secretion of crucial soluble factors without altering cell viability. At the same time, the array exhibits effective bactericidal properties against Gram-positive and Gram-negative bacteria. In vivo studies further demonstrate that the flexible hydrogel patch with its spiky vertical nanostructures significantly promotes the regeneration of damaged cranial bone tissues while suppressing pathogenic bacterial infections in mouse models.
URI
https://scholarworks.unist.ac.kr/handle/201301/27837
URL
https://pubs.acs.org/doi/10.1021/acsnano.9b04109
DOI
10.1021/acsnano.9b04109
ISSN
1936-0851
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