Biomolecular motor-driven molecular sorter
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- Biomolecular motor-driven molecular sorter
- Kim, Taesung; Cheng, Li-Jing; Kao, Ming-Tse; Hasselbrink, Ernest F.; Guo, LingJie; Meyhoefer, Edgar
- MICROTUBULE TRANSPORT; ELECTRIC-FIELDS; KINESIN; CHANNELS; ALIGNMENT; DIRECTION; TRACKS
- Issue Date
- ROYAL SOC CHEMISTRY
- LAB ON A CHIP, v.9, no.9, pp.1282 - 1285
- We have developed a novel, microfabricated, stand-alone microfluidic device that can efficiently sort and concentrate (bio-)analyte molecules by using kinesin motors and microtubules as a chemo-mechanical transduction machine. The device removes hundreds of targeted molecules per second from an analyte stream by translocating functionalized microtubules with kinesin across the stream and concentrating them at a horseshoe-shaped collector. Target biomolecule concentrations increase up to three orders of magnitude within one hour of operation.
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