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Kim, Taesung
Microfluidics & Nanomechatronics Lab (μFNM)
Research Interests
  • Micro-/Nanofluidics

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Biomolecular motor-driven molecular sorter

Cited 19 times inthomson ciCited 17 times inthomson ci
Title
Biomolecular motor-driven molecular sorter
Author
Kim, TaesungCheng, Li-JingKao, Ming-TseHasselbrink, Ernest F.Guo, LingJieMeyhoefer, Edgar
Keywords
MICROTUBULE TRANSPORT; ELECTRIC-FIELDS; KINESIN; CHANNELS; ALIGNMENT; DIRECTION; TRACKS
Issue Date
2009
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.9, no.9, pp.1282 - 1285
Abstract
We have developed a novel, microfabricated, stand-alone microfluidic device that can efficiently sort and concentrate (bio-)analyte molecules by using kinesin motors and microtubules as a chemo-mechanical transduction machine. The device removes hundreds of targeted molecules per second from an analyte stream by translocating functionalized microtubules with kinesin across the stream and concentrating them at a horseshoe-shaped collector. Target biomolecule concentrations increase up to three orders of magnitude within one hour of operation.
URI
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DOI
http://dx.doi.org/10.1039/b900753a
ISSN
1473-0197
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MNE_Journal Papers

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