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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Fully integrated lab-on-a-disc for simultaneous analysis of biochemistry and immunoassay from whole blood

Cited 55 times inthomson ciCited 45 times inthomson ci
Title
Fully integrated lab-on-a-disc for simultaneous analysis of biochemistry and immunoassay from whole blood
Author
Lee, Beom SeokLee, Yang UiKim, Han-SangKim, Tae-HyeongPark, JiwoonLee, Jeong-GunKim, JintaeKim, HanshinLee, Wee GyoCho, Yoon-Kyoung
Keywords
CENTRIFUGAL MICROFLUIDICS; ANALYSIS SYSTEM; COMPACT DISC; PLATFORM; DEVICE; DIAGNOSTICS; EXTRACTION; ASSAYS; CHIP
Issue Date
2011-01
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.11, no.1, pp.70 - 78
Abstract
We report a fully integrated device that can perform both multiple biochemical analysis and sandwich type immunoassay simultaneously on a disc. The whole blood is applied directly to the disposable "lab-on-a-disc" containing different kinds of freeze-dried reagents for the blood chemistry analysis as well as reagents required for the immunoassay. The concentrations of different kinds of analytes are reported within 22 min by simply inserting a disc to a portable device. Using the innovative laser irradiated ferrowax microvalves together with the centrifugal microfluidics, the total process of plasma separation, metering, mixing, incubation, washing, and detection is fully automated. The analyzer is equipped with an optical detection module to measure absorbances at 10 different wavelengths to accommodate the various kinds of reaction protocols. Compared to the conventional blood analysis done in clinical laboratories, it is advantageous for point-of-care applications because it requires a smaller amount of blood (350 mu L vs. 3 mL), takes less time (22 min vs. several days), does not require specially trained operators or expensive instruments to run biochemical analysis and immunoassay separately.
URI
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DOI
10.1039/c0lc00205d
ISSN
1473-0197
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SLS_Journal Papers
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