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Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Rounded multi-level microchannels with orifices made in one exposure enable aqueous two-phase system droplet microfluidics

Cited 7 times inthomson ciCited 8 times inthomson ci
Title
Rounded multi-level microchannels with orifices made in one exposure enable aqueous two-phase system droplet microfluidics
Author
Lai, DavidFrampton, John P.Hari, Sriram A.Takayama, Shuichi
Keywords
CELL-CULTURE
Issue Date
2011-10
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.11, no.20, pp.3551 - 3554
Abstract
Exposure of a negative photoresist-coated glass slide with diffused light from the backside through a mask with disconnected features provides multi-level rounded channels with narrow orifices in one exposure. Using these structures, we construct microfluidic systems capable of creating aqueous two-phase system droplets where one aqueous phase forms droplets and the other aqueous phase forms the surrounding matrix. Unlike water-in-oil droplet systems, aqueous two-phase systems can have very low interfacial tensions that prevent spontaneous droplet formation. The multi-level channels fabricated by backside lithography satisfy two conflicting needs: (i) the requirement to have narrowed channels for efficient valve closure by channel deformation and (ii) the need to have wide channels to reduce the flow velocity, thus reducing the capillary number and enhancing droplet formation
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DOI
10.1039/c1lc20560a
ISSN
1473-0197
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SLS_Journal Papers
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