There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 728 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.contributor.author | Hong, Ye | - |
dc.contributor.author | Sonneville, Remi | - |
dc.contributor.author | Wang, Bin | - |
dc.contributor.author | Scheidt, Viktor | - |
dc.contributor.author | Meier, Bettina | - |
dc.contributor.author | Woglar, Alexander | - |
dc.contributor.author | Demetriou, Sarah | - |
dc.contributor.author | Labib, Karim | - |
dc.contributor.author | Jantsch, Verena | - |
dc.contributor.author | Gartner, Anton | - |
dc.date.accessioned | 2023-12-21T21:08:55Z | - |
dc.date.available | 2023-12-21T21:08:55Z | - |
dc.date.created | 2019-09-10 | - |
dc.date.issued | 2018-02 | - |
dc.description.abstract | Faithful chromosome segregation and genome maintenance requires the removal of all DNA bridges that physically link chromosomes before cells divide. Using C. elegans embryos we show that the LEM-3/Ankle1 nuclease defines a previously undescribed genome integrity mechanism by processing DNA bridges right before cells divide. LEM-3 acts at the midbody, the structure where abscission occurs at the end of cytokinesis. LEM-3 localization depends on factors needed for midbody assembly, and LEM-3 accumulation is increased and prolonged when chromatin bridges are trapped at the cleavage plane. LEM-3 locally processes chromatin bridges that arise from incomplete DNA replication, unresolved recombination intermediates, or the perturbance of chromosome structure. Proper LEM-3 midbody localization and function is regulated by AIR-2/Aurora B kinase. Strikingly, LEM-3 acts cooperatively with the BRC-1/BRCA1 homologous recombination factor to promote genome integrity. These findings provide a molecular basis for the suspected role of the LEM-3 orthologue Ankle1 in human breast cancer. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9, pp.728 | - |
dc.identifier.doi | 10.1038/s41467-018-03135-w | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-85042223919 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/27473 | - |
dc.identifier.url | https://www.nature.com/articles/s41467-018-03135-w | - |
dc.identifier.wosid | 000425504500005 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | C. ELEGANS EMBRYOS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | ANAPHASE BRIDGES | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | CYTOKINESIS | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | COMPLETION | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.