There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 77 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 65 | - |
dc.contributor.author | Pelisch, Federico | - |
dc.contributor.author | Tammsalu, Triin | - |
dc.contributor.author | Wang, Bin | - |
dc.contributor.author | Jaffray, Ellis G. | - |
dc.contributor.author | Gartner, Anton | - |
dc.contributor.author | Hay, Ronald T. | - |
dc.date.accessioned | 2023-12-21T22:42:20Z | - |
dc.date.available | 2023-12-21T22:42:20Z | - |
dc.date.created | 2019-09-10 | - |
dc.date.issued | 2017-01 | - |
dc.description.abstract | During Caenorhabditis elegans oocyte meiosis, a multi-protein ring complex (RC) localized between homologous chromosomes, promotes chromosome congression through the action of the chromokinesin KLP-19. While some RC components are known, the mechanism of RC assembly has remained obscure. We show that SUMO E3 ligase GEI-17/PIAS is required for KLP-19 recruitment to the RC, and proteomic analysis identified KLP-19 as a SUMO substrate in vivo. In vitro analysis revealed that KLP-19 is efficiently sumoylated in a GEI-17-dependent manner, while GEI-17 undergoes extensive auto-sumoylation. GEI-17 and another RC component, the kinase BUB-1, contain functional SUMO interaction motifs (SIMs), allowing them to recruit SUMO modified proteins, including KLP-19, into the RC. Thus, dynamic SUMO modification and the presence of SIMs in RC components generate a SUMO-SIM network that facilitates assembly of the RC. Our results highlight the importance of SUMO-SIM networks in regulating the assembly of dynamic protein complexes. | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.65, no.1, pp.66 - 77 | - |
dc.identifier.doi | 10.1016/j.molcel.2016.11.001 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.scopusid | 2-s2.0-85008166412 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/27444 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1097276516307092?via%3Dihub | - |
dc.identifier.wosid | 000395635300008 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | SEGREGATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | SUMOYLATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MODIFIER | - |
dc.subject.keywordPlus | BODY | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.