Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps
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- Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps
- Wu, Jiahao; Chantiwas, Rattikan; Amirsadeghi, Alborz; Soper, Steven A.; Park, Sunggook
- CHANNELS; NANOCHANNELS; FABRICATION; LITHOGRAPHY; MOLECULES; FLOW
- Issue Date
- ROYAL SOC CHEMISTRY
- LAB ON A CHIP, v.11, no.17, pp.2984 - 2989
- Development of all polymer-based nanofluidic devices using replication technologies, which is a prerequisite for providing devices for a larger user base, is hampered by undesired substrate deformation associated with the replication of multi-scale structures. Therefore, most nanofluidic devices have been fabricated in glass-like substrates or in a polymer resist layer coated on a substrate. This letter presents a rapid, high fidelity direct imprinting process to build polymer nanofluidic devices in a single step. Undesired substrate deformation during imprinting was significantly reduced through the use of a polymer stamp made from a UV-curable resin. The integrity of the enclosed all polymer-based nanofluidic system was verified by a fluorescein filling experiment and translocation/ stretching of lambda-DNA molecules through the nanochannels. It was also found that the funnel-like design of the nanochannel inlet significantly improved the entrance of DNA molecules into nanochannels compared to an abrupt nanochannel/microfluidic network interface.
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