Cellulose acetate nanoneedle array covered with phosphorylcholine moiety as a biocompatible and sustainable antifouling material
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- Cellulose acetate nanoneedle array covered with phosphorylcholine moiety as a biocompatible and sustainable antifouling material
- Park, Hyun-Ha; Sun, Kahyun; Lee, Dongjin; Seong, Minho; Cha, Chaenyung; Jeong, Hoon Eui
- Issue Date
- CELLULOSE, v.26, no.16, pp.8775 - 8788
- Extensive efforts have been devoted toward developing antibiofilm materials that can efficiently suppress bacterial attachment and subsequent biofilm formation. However, many of the previous approaches are based on non-biocompatible, non-degradable, and environmentally harmful synthetic materials. Herein, we report an efficient and sustainable biofilm-resistant material that is made of a biocompatible, biodegradable, and naturally abundant cellulose derivate biopolymer. The biofilm-resistant material is made of cellulose acetate (CA) and possesses precisely defined nanoscale needle-like architectures on its surface. The CA nanoneedle array is further coated with a cell-membrane mimicking monomer of 2-methacryloryloxyethyl phosphorylcholine (MPC). Based on the synergetic integration of the bio- and environment-friendly polymers of CA and MPC into nanoscale topography, the nanostructured CA not only effectively prevents bacterial attachment but also simultaneously exhibits strong bactericidal effects against both gram-positive and gram-negative bacteria. This natural cellulose derivative-based nanostructured material has strong potential as a biocompatible, and eco-friendly antibiofilm material for versatile uses in biomedical and industrial applications.
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