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Intertwined Pathologies of Amyloid-beta and Metal Ions in Alzheimer's Disease: Metal-Amyloid-beta

Author(s)
Nam, Geewoo, Lim, Mi Hee
Issued Date
2019-08
DOI
10.1246/cl.190281
URI
https://scholarworks.unist.ac.kr/handle/201301/27265
Fulltext
https://www.journal.csj.jp/doi/10.1246/cl.190281
Citation
CHEMISTRY LETTERS, v.48, no.8, pp.951 - 960
Abstract
Both amyloid-beta (A beta) and metal ions are implicated in the pathology of Alzheimer's disease (AD). Research efforts elucidating the pathogenic roles of these two biological components denote a connection between them. This highlight review presents the current understanding of A beta and metal ions in AD and their relationship prompting a hybrid concept: metal-bound A beta (metal-A beta).
Publisher
CHEMICAL SOC JAPAN
ISSN
0366-7022
Keyword (Author)
Amyloid-beta, Metal ions, Metal-amyloid-beta
Keyword
TARGETING A-BETA, HYDROGEN-PEROXIDE, PRECURSOR PROTEIN, IN-VITRO, SECONDARY NUCLEATION, PEPTIDE AGGREGATION, SMALL MOLECULES, CHEMICAL TOOLS, COPPER, ZINC

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