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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Phosphate-Functionalized Stabilized F127 Nanoparticles: Introduction of Discrete Surface Charges and Electrophoretic Determination of Aggregation Number

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Title
Phosphate-Functionalized Stabilized F127 Nanoparticles: Introduction of Discrete Surface Charges and Electrophoretic Determination of Aggregation Number
Author
Hwang, JuyoungKang, MingyeongSari, Mila IrvaLee, Tae HyeongKim, KibeomChoi, Yeol KyoLee, EunjiRyu, Ja-HyoungBaek, Seung KiAhn, Dong JunLee, Peter C.W.Kwak, Minseok
Issue Date
2019-07
Publisher
한국고분자학회
Citation
MACROMOLECULAR RESEARCH, v.27, no.7, pp.657 - 662
Abstract
Pluronic F127 forms spherical micelle with a defined number of molecules aggregated in aqueous environments. Such self-assembled micelles dissociate into unimers below certain concentration and temperature. We stabilized the micelles by semi-interpenetrating network (sIPN) formation within the hydrophobic core in the presence of a fluorescent dye. Additionally, by varying the mixing ratio of negatively charged and pristine F127s we prepared thermally stable polymeric nanoparticles with discrete surface charges within nearly same sizes. Using the nanomaterials with prescribed number of charges, we demonstrate that the electrophoretic mobility of nanoparticles is solely depending on number of surface charges. Finally, the aggregation number (Nagg) of F127 was further determined by electrophoresis.
URI
https://scholarworks.unist.ac.kr/handle/201301/27187
URL
https://link.springer.com/article/10.1007/s13233-019-7100-x
DOI
10.1007/s13233-019-7100-x
ISSN
1598-5032
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CHM_Journal Papers
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