File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Author(s)
Savelieff, Masha G.Nam, GeewooKang, JuhyeLee, Hyuck JinLee, MisunLim, Mi Hee
Issued Date
2019-01
DOI
10.1021/acs.chemrev.8b00138
URI
https://scholarworks.unist.ac.kr/handle/201301/26452
Fulltext
https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00138
Citation
CHEMICAL REVIEWS, v.119, no.2, pp.1221 - 1322
Abstract
Neurodegenerative diseases pose a substantial socioeconomic burden on society. Unfortunately, the aging world population and lack of effective cures foreshadow a negative outlook. Although a large amount of research has been dedicated to elucidating the pathologies of neurodegenerative diseases, their principal causes remain elusive. Metal ion dyshomeostasis, proteopathy, oxidative stress, and neurotransmitter deficiencies are pathological features shared across multiple neurodegenerative disorders. In addition, these factors are proposed to be interrelated upon disease progression. Thus, the development of multifunctional compounds capable of simultaneously interacting with several pathological components has been suggested as a solution to undertake the complex pathologies of neurodegenerative diseases. In this review, we outline and discuss possible therapeutic targets in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis and molecules, previously designed or discovered as potential drug candidates for these disorders with emphasis on multifunctionality. In addition, underrepresented areas of research are discussed to indicate new directions.
Publisher
American Chemical Society
ISSN
0009-2665
Keyword
AMYLOID-BETA-PEPTIDEMONOAMINE-OXIDASE-BALPHA-SYNUCLEIN AGGREGATIONMULTITARGET-DIRECTED LIGANDSPAIRED HELICAL FILAMENTSTRANSGENIC MOUSE MODELMETAL-CHELATING PROPERTIESMANNICH BASE DERIVATIVESMOTOR-NEURON DISEASEDRUG DESIGN STRATEGY

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.