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- Namgung, Seon
- Quantum Device Lab.
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Family-selective detection of antibiotics using antibody-functionalized carbon nanotube sensors
- Author(s)
- Kim, Byeongju, Lim, Donghyun, Jin, Hye Jun, Lee, Hyang Yeon, Namgung, Seon, Ko, Yeonjin, Park, Seung Bum, Hong, Seunghun
- Issued Date
- 2012-05
- Citation
- SENSORS AND ACTUATORS B-CHEMICAL, v.166-167, pp.193 - 199
- Abstract
- The development of a rapid and sensitive detection method for well-known, yet abused, antibiotics has been an important issue for food safety and environmental protection. This paper presents a simple and sensitive method for the specific or family-selective detection of antibiotics using carbon nanotube (CNT)-based sensors. Herein, CNT-based sensor transducers were functionalized with the single-chain variable-fragment (scFv) of antibodies that can selectively bind to a specific antibiotic or the certain family of antibiotics. Our CNT-based sensors functionalized with A2 scFv or F9 scFv exhibited the specific detection of enrofloxacin or the family-selective detection of fluoroquinolone-based antibiotics, respectively, in a real-time manner. This simple but efficient strategy can be utilized for various applications in the fields of food safety and environmental protection. (C) 2012 Elsevier B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE SA
- ISSN
- 0925-4005
- Keyword (Author)
- Antibiotic, Carbon nanotube, Sensor, Family-selective detection, Enrofloxacin, Norfloxacin
- Keyword
- ENROFLOXACIN, BIOSENSOR
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