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- Bae, Han Yong
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Ultrasound-Promoted Enantioselective Decarboxylative Protonation of alpha-Aminomalonate Hemiesters by Chiral Squaramides: A Practical Approach to Both Enantiomers of alpha-Amino Esters
- Author(s)
- Some, Surajit, Bae, Han Yong, Kim, Mun Jong, Zhang, Yong Jian, Song, Choong Eui
- Issued Date
- 2017-08
- Citation
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2017, no.31, pp.4562 - 4565
- Abstract
- Herein, we report an ultrasound-promoted enantio-selective decarboxylative protonation reaction of alpha-aminomalonate hemiesters 1 in the presence of chiral cinchona-derived squaramide Bronsted bases under mild conditions, which afforded both the (S)- and (R)-enantiomers of alpha-amino acid derivatives 2 in excellent yields (>90 %) and excellent enantioselectivities (up to 98 % ee).
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 1434-193X
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