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Cho, Seung Woo
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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

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Title
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Author
Cho, Seung WooKim, SojungKim, Jong MinKim, Jin-Soo
Issue Date
2013-03
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE BIOTECHNOLOGY, v.31, no.3, pp.230 - 232
Abstract
We employ the CRISPR-Cas system of Streptococcus pyogenes as programmable RNA-guided endonucleases (RGENs) to cleave DNA in a targeted manner for genome editing in human cells. We show that complexes of the Cas9 protein and artificial chimeric RNAs efficiently cleave two genomic sites and induce indels with frequencies of up to 33%.
URI
https://scholarworks.unist.ac.kr/handle/201301/25770
URL
https://www.nature.com/articles/nbt.2507
DOI
10.1038/nbt.2507
ISSN
1087-0156
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