Full metadata record
DC Field | Value | Language |
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dc.citation.title | FRONTIERS IN PHYSIOLOGY | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Halterman, Julia A. | - |
dc.contributor.author | Kwon, H. Moo | - |
dc.contributor.author | Leitinger, Norbert | - |
dc.contributor.author | Wamhoff, Brian R. | - |
dc.date.accessioned | 2023-12-22T04:47:34Z | - |
dc.date.available | 2023-12-22T04:47:34Z | - |
dc.date.created | 2013-07-11 | - |
dc.date.issued | 2012-08 | - |
dc.description.abstract | Objective: We have previously shown that the transcription factor, nuclear factor of activated T-cells 5 (NFAT5), regulates vascular smooth muscle cell phenotypic modulation, but the role of NFAT5 in atherosclerosis is unknown. Our main objective was to determine if NFAT5 expression in bone marrow (BM)-derived cells altered atherosclerotic development and macrophage function. Methods and Results: NFAT5+/-ApoE-/- mice were generated for in vivo atherosclerosis studies. Following high fat diet feeding, en face analysis of the thoracic aorta established that genome-wide NFAT5 haploinsufficiency reduced atherosclerotic lesion formation by 73%. BM transplant studies revealed that transplantation of NFAT5+/-ApoE-/- marrow into NFAT5+/+ApoE-/- mice resulted in a similar 86% reduction in lesion formation. In vitro functional analysis of BM-derived macrophages demonstrated that NFAT5 is required for macrophage migration, which is a key event in the propagation of atherosclerosis. Conclusion: We have identified NFAT5 in BM-derived cells as a positive regulator of atherosclerotic lesion formation and macrophage function in the vasculature. | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHYSIOLOGY, v.3 | - |
dc.identifier.doi | 10.3389/fphys.2012.00313 | - |
dc.identifier.issn | 1664-042X | - |
dc.identifier.scopusid | 2-s2.0-84866502277 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2545 | - |
dc.identifier.wosid | 000209173000307 | - |
dc.language | 영어 | - |
dc.publisher | FRONTIERS | - |
dc.title | NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Bone marrow | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | Migration | - |
dc.subject.keywordAuthor | Tonebp | - |
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