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김용환

Kim, Yong Hwan
Enzyme and Protein Engineering Lab.
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A Photoenzymatic NADH regeneration system

Author(s)
Hçfler, Georg T.Fernandes-Fueyo, ElenaPesic, MiljaYounes, Sabry H.Choi, Eun-GyuKim, Yong HwanUrlacher, Vlada B.Arends, Isabel W. C. E.Hollmann, Frank
Issued Date
2018-09
DOI
10.1002/cbic.201800530
URI
https://scholarworks.unist.ac.kr/handle/201301/25158
Fulltext
https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201800530
Citation
CHEMBIOCHEM, v.19, no.22, pp.2344 - 2347
Abstract
A photoenzymatic NADH regeneration system was established. The combination of deazariboflavin as a photocatalyst with putidaredoxin reductase enabled the selective reduction of NAD+ into the enzyme‐active 1,4‐NADH to promote an alcohol dehydrogenase catalysed stereospecific reduction reaction. The catalytic turnover of all the reaction components was demonstrated. Factors influencing the efficiency of the overall system were identified.
Publisher
WILEY-V C H VERLAG GMBH
ISSN
1439-4227
Keyword (Author)
biocatalysisenantioselectivityketonesphotochemistryreduction
Keyword
NICOTINAMIDE COFACTORSREDUCTIONOXIDATIONCOENZYMES

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