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Kim, Jae-Ick
Neural Circuit and Neurodegenerative Disease Lab.
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DC Field Value Language
dc.citation.endPage 1449 -
dc.citation.number 6 -
dc.citation.startPage 1436 -
dc.citation.title CELL -
dc.citation.volume 174 - Maeder, Celine I. - Kim, Jae-Ick - Liang, Xing - Kaganovsky, Konstantin - Shen, Ao - Li, Qin - Li, Zhaoyu - Wang, Sui - Xu, X. Z. Shawn - Li, Jin Billy - Xiang, Yang Kevin - Ding, Jun B. - Shen, Kang - 2023-12-21T20:14:20Z - 2023-12-21T20:14:20Z - 2018-10-10 - 2018-09 -
dc.description.abstract Synaptic vesicle and active zone proteins are required for synaptogenesis. The molecular mechanisms for coordinated synthesis of these proteins are not understood. Using forward genetic screens, we identified the conserved THO nuclear export complex (THOC) as an important regulator of presynapse development in C. elegans dopaminergic neurons. In THOC mutants, synaptic messenger RNAs are retained in the nucleus, resulting in dramatic decrease of synaptic protein expression, near complete loss of synapses, and compromised dopamine function. CRE binding protein (CREB) interacts with THOC to mark synaptic transcripts for efficient nuclear export. Deletion of Thoc5, a THOC subunit, in mouse dopaminergic neurons causes severe defects in synapse maintenance and subsequent neuronal death in the substantia nigra compacta. These cellular defects lead to abrogated dopamine release, ataxia, and animal death. Together, our results argue that nuclear export mechanisms can select specific mRNAs and be a rate-limiting step for neuronal differentiation and survival. -
dc.identifier.bibliographicCitation CELL, v.174, no.6, pp.1436 - 1449 -
dc.identifier.doi 10.1016/j.cell.2018.07.046 -
dc.identifier.issn 0092-8674 -
dc.identifier.scopusid 2-s2.0-85053852929 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000443841000013 -
dc.language 영어 -
dc.publisher CELL PRESS -
dc.title The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival -
dc.type Article -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Cell Biology -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Cell Biology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus MESSENGER-RNA-EXPORT -
dc.subject.keywordPlus CAENORHABDITIS-ELEGANS -
dc.subject.keywordPlus NERVOUS-SYSTEM -
dc.subject.keywordPlus NUCLEAR EXPORT -
dc.subject.keywordPlus IN-VIVO -
dc.subject.keywordPlus CREB -
dc.subject.keywordPlus PROTEIN -
dc.subject.keywordPlus PLASTICITY -
dc.subject.keywordPlus MOUSE -


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