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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 7818 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 7812 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 279 | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Kwak, Noh-Jin | - |
dc.contributor.author | Lee, Joo Yong | - |
dc.contributor.author | Choi, BH | - |
dc.contributor.author | Lim, Y | - |
dc.contributor.author | Ko, YJ | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Huh, PW | - |
dc.contributor.author | Lee, KH | - |
dc.contributor.author | Rha, HK | - |
dc.contributor.author | Wang, YP | - |
dc.date.accessioned | 2023-12-22T11:06:58Z | - |
dc.date.available | 2023-12-22T11:06:58Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2004-02 | - |
dc.description.abstract | The stability of p53 tumor suppressor is regulated by Mdm2 via the ubiquitination and proteasome-mediated proteolysis pathway. The c-Abl and PTEN tumor suppressors are known to stabilize p53 by blocking the Mdm2-mediated p53 degradation. This study investigated the correlation between p53 and merlin, a neurofibromatosis 2 ( NF2)-related tumor suppressor, in association with the Mdm2 function. The results showed that merlin increased the p53 stability by inhibiting the Mdm2-mediated degradation of p53, which accompanied the increase in the p53-dependent transcriptional activity. The stabilization of p53 by merlin appeared to be accomplished through Mdm2 degradation, and the N-terminal region of merlin was responsible for this novel activity. This study also showed that overexpression of merlin-induced apoptosis of cells depending preferentially on p53 in response to the serum starvation or a chemotherapeutic agent. These results suggest that merlin could be a positive regulator of p53 in terms of tumor suppressor activity, and provide the promising therapeutic means for treating tumors with non-functional merlin or Mdm2 overexpression. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.279, no.9, pp.7812 - 7818 | - |
dc.identifier.doi | 10.1074/jbc.M305526200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-10744229026 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24916 | - |
dc.identifier.url | http://www.jbc.org/content/279/9/7812 | - |
dc.identifier.wosid | 000189103300056 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Merlin neutralizes the inhibitory effect of Mdm2 on p53 | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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