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DC Field | Value | Language |
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dc.citation.endPage | 5364 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | 5355 | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 24 | - |
dc.contributor.author | Ryu, Chung Hun | - |
dc.contributor.author | Kim, Sae-Woong | - |
dc.contributor.author | Lee, Kyu Hwa | - |
dc.contributor.author | Lee, Joo Yong | - |
dc.contributor.author | Kim, Hpongtae | - |
dc.contributor.author | Lee, Woon Kyu | - |
dc.contributor.author | Choi, Byung Hyune | - |
dc.contributor.author | Lim, Young | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Lee, Kweon-Haeng | - |
dc.contributor.author | Hwang, Tae-Kon | - |
dc.contributor.author | Jun, Tae-Youn | - |
dc.contributor.author | Rha, Hyoung Kyun | - |
dc.date.accessioned | 2023-12-22T10:14:08Z | - |
dc.date.available | 2023-12-22T10:14:08Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2005-08 | - |
dc.description.abstract | Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein-protein interactions with various cellular proteins. In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and Ral guanine nucleotide dissociation stimulator (RalGDS), a downstream molecule of Ras, was identified as a merlin-binding protein. The direct interaction between merlin and RalGDS was confirmed both in vitro and in the NIH3T3 cells. The domain analyses revealed that the broad C-terminal region of merlin (aa 141-595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RalGDS. Functional studies showed that merlin inhibits the RalGDS-induced RalA activation, the colony formation and the cell migration in mammalian cells. These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals. | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.24, no.34, pp.5355 - 5364 | - |
dc.identifier.doi | 10.1038/sj.onc.1208633 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.scopusid | 2-s2.0-24044521938 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24914 | - |
dc.identifier.url | https://www.nature.com/articles/1208633 | - |
dc.identifier.wosid | 000231158500009 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | NF2 | - |
dc.subject.keywordAuthor | merlin | - |
dc.subject.keywordAuthor | tumor suppressor | - |
dc.subject.keywordAuthor | RalGDS | - |
dc.subject.keywordAuthor | oncogenic signals | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | NEUROFIBROMATOSIS TYPE-2 | - |
dc.subject.keywordPlus | GENE-PRODUCT | - |
dc.subject.keywordPlus | CELLULAR-TRANSFORMATION | - |
dc.subject.keywordPlus | BINDING PROTEIN-1 | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | SPLICED ISOFORMS | - |
dc.subject.keywordPlus | FERM DOMAIN | - |
dc.subject.keywordPlus | SCHWANNOMIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
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