There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1157 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1151 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 340 | - |
dc.contributor.author | Lim, Jung Yeon | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Jeun, Sin-Soo | - |
dc.contributor.author | Kang, Seok-Gu | - |
dc.contributor.author | Lee, Kyung-Jin | - |
dc.date.accessioned | 2023-12-22T10:08:03Z | - |
dc.date.available | 2023-12-22T10:08:03Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2006-02 | - |
dc.description.abstract | Numerous studies have suggested that the NF2 protein merlin is involved in the regulation of abnormal cell growth and proliferation. In this study, to better understand the merlin's mechanisms that contribute to the inhibition of tumorigenesis, we examined the potential action of merlin on the cell proliferative signaling pathways in response to growth hormone (GH). Merlin effectively attenuated the GH-induced serum response element (SRE) and Elk-l-mediated transcriptional activation, as well as the endogenous SRE-regulated gene c-fos expression in NIH3T3 cells. In addition, merlin prevented the Raf-1 complex activation process, which resulted in the suppression of MAP kinase/ERK, extracellular signal-regulated kinase (ERKs), and Elk-1 phosphorylation, which are the downstream signals of Raf-1. Moreover, it was shown that merlin interacted with endogenous growth factor receptor bound 2 (Grb2) protein and inhibited its expression. These results suggest that merlin contributes, via its protein-to-protein interaction with Grb2 and consequent inhibition of the MAPK pathways, to the regulation of the abnormal cell proliferation, and this provides a further mechanism underlying the tumor suppressor function of merlin. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.340, no.4, pp.1151 - 1157 | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.12.122 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-30544432960 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24912 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X05028561?via%3Dihub | - |
dc.identifier.wosid | 000235041500020 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | neurofibromatosis type 2 | - |
dc.subject.keywordAuthor | merlin | - |
dc.subject.keywordAuthor | raf-1 activation | - |
dc.subject.keywordAuthor | growth factor receptor bound 2 | - |
dc.subject.keywordAuthor | proliferative signals | - |
dc.subject.keywordPlus | SERUM RESPONSE ELEMENT | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | C-FOS | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | KINASE-ACTIVITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PRODUCT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | RECEPTOR | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.