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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1205 | - |
dc.citation.number | 5828 | - |
dc.citation.startPage | 1202 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 316 | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Chen, Junjie | - |
dc.contributor.author | Yu, Xiaochun | - |
dc.date.accessioned | 2023-12-22T09:14:39Z | - |
dc.date.available | 2023-12-22T09:14:39Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2007-05 | - |
dc.description.abstract | Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA damage response. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. RAP80 contains a tandem ubiquitin-interacting motif domain, which is required for its binding with ubiquitin in vitro and its damage-induced foci formation in vivo. Moreover, RAP80 specifically recruits BRCA1 to DNA damage sites and functions with BRCA1 in G(2)/M checkpoint control. Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response. | - |
dc.identifier.bibliographicCitation | SCIENCE, v.316, no.5828, pp.1202 - 1205 | - |
dc.identifier.doi | 10.1126/science.1139621 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.scopusid | 2-s2.0-34249950879 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24911 | - |
dc.identifier.url | http://science.sciencemag.org/content/316/5828/1202 | - |
dc.identifier.wosid | 000246724300046 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | BRCA1 | - |
dc.subject.keywordPlus | CHECKPOINT | - |
dc.subject.keywordPlus | BRCA1-BARD1 | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | LIGASE | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | FANCD2 | - |
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