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DC Field | Value | Language |
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dc.citation.endPage | 346 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 339 | - |
dc.citation.title | JOURNAL OF NEURO-ONCOLOGY | - |
dc.citation.volume | 97 | - |
dc.contributor.author | Lim, Jung Yeon | - |
dc.contributor.author | Oh, Ji Hyeon | - |
dc.contributor.author | Jung, Ju Ri | - |
dc.contributor.author | Kim, Seong Muk | - |
dc.contributor.author | Ryu, Chung Hun | - |
dc.contributor.author | Kim, Hong-Tae | - |
dc.contributor.author | Jeun, Sin-Soo | - |
dc.date.accessioned | 2023-12-22T07:08:51Z | - |
dc.date.available | 2023-12-22T07:08:51Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2010-05 | - |
dc.description.abstract | Mounting evidence suggests that lipoxygenase (LO)-catalyzed products may play a key role in the development and progression of human cancers. In this study, we analyzed the effects of a 5-LO inhibitor, which inhibits the conversion of arachidonic acid to leukotrienes, on cell proliferation and apoptosis in human malignant glioma cells, including 5-LO-expressing cells U-87MG, A172 and 5-LO non-expressing cell U373. Growth of U-87MG and A172 cells, but not that of U373 cells, was inhibited in a dose-dependent manner by treatment with MK886. Similarly, specific 5-LO silencing by small interfering RNA reduced the growth of U-87MG and A172 cells. MK886 treatment reduced 5-LO activity independently of 5-LO-activating protein (FLAP) in human malignant glioma cells. MK886 treatment also induced cell apoptosis, measured by DNA fragmentation and nuclear condensation, in U-87MG and A172 cells but there were no signs in U373 cells. Moreover, this treatment reduced ERKs phosphorylation and anti-apoptotic molecule Bcl-2 expression, and increased Bax expression in U-87MG and A172 cells. In summary, our results show there is a link between the 5-LO expression status and the extent of MK886-inhibited cell proliferation and apoptosis. Taken together, this study suggest that 5-LO is a possible target for treating patients with gliomas, and 5-LO inhibition might be potent therapy for patients with 5-LO-expressing malignant gliomas. | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, v.97, no.3, pp.339 - 346 | - |
dc.identifier.doi | 10.1007/s11060-009-0036-9 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.scopusid | 2-s2.0-77953290988 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24903 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs11060-009-0036-9 | - |
dc.identifier.wosid | 000278349200003 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER | - |
dc.title | MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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