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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 362 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 355 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 30 | - |
dc.contributor.author | Cho, Hyun Jung | - |
dc.contributor.author | Oh, Yun Jeong | - |
dc.contributor.author | Kwon, Junhye | - |
dc.contributor.author | Kwon, Jae Young | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.contributor.author | Kim, Hongtae | - |
dc.date.accessioned | 2023-12-22T06:41:42Z | - |
dc.date.available | 2023-12-22T06:41:42Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2010-10 | - |
dc.description.abstract | c-Myc is a cellular onco-protein and a transcriptional activator important for cell growth, cell division, and tumorigenesis. Despite all that is known of its function, the mechanism of how c-Myc contributes to tumorigenesis is unclear. To gain insight into the mechanism through which c-Myc protein exerts its oncogenic activity, we performed large-scale, tandem repeat affinity purification and identified the F box only protein 8 (FBX8), an F-box and Sec7 domain-containing protein, as a novel Myc-binding protein. The c-Myc/FBX8 interaction was mediated by the c-Myc box II (MBII) region. We also confirmed that Myc protein overexpression in 293T cells affected FBX8 cellular translocation and led to recovery from FBX8-mediated inhibition of ADP-ribosylation factor 6 (ARF6) function during cell invasion. Together, these results suggest that FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity through the inhibition of FBX8 effects on ARF6 function during cell invasion. | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.30, no.4, pp.355 - 362 | - |
dc.identifier.doi | 10.1007/s10059-010-0134-8 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-78650516735 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24901 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10059-010-0134-8 | - |
dc.identifier.wosid | 000284700000010 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | c-Myc Stimulates Cell Invasion by Inhibiting FBX8 Function | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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