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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1174 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1169 | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Chae, Su Young | - |
dc.contributor.author | Kim, Hyun June | - |
dc.contributor.author | Lee, Min Sang | - |
dc.contributor.author | Jang, Yeon Lim | - |
dc.contributor.author | Lee, Yuhan | - |
dc.contributor.author | Lee, Soo Hyeon | - |
dc.contributor.author | Lee, Kyuri | - |
dc.contributor.author | Kim, Sun Hwa | - |
dc.contributor.author | Kim, Hong Tae | - |
dc.contributor.author | Chi, Sang-Cheol | - |
dc.contributor.author | Park, Tae Gwan | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.date.accessioned | 2023-12-22T05:45:30Z | - |
dc.date.available | 2023-12-22T05:45:30Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2011-09 | - |
dc.description.abstract | Efficient gene transfer into mammalian cells mediated by small molecular amphiphile-polymer conjugates, bile acid-polyethylenimine (BA-PEI), is demonstrated, opening an efficient transport route for genetic materials across the cell membrane. This process occurs without the aid of endocytosis or other energy-consuming processes, thus mimicking macromolecular transduction by cell-penetrating peptides. The exposure of a hydrophilic face of the amphiphilic BA moiety on the surface of BA-PEI/DNA complex that mediates direct contact of the BA molecules to the cell surface seems to play an important role in the endocytosis- and energy-independent internalization process. The new modality of the polymeric biomimetics can be applied to enhanced delivery of macromolecular therapeutics. | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.11, no.9, pp.1169 - 1174 | - |
dc.identifier.doi | 10.1002/mabi.201100088 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.scopusid | 2-s2.0-80052447684 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24898 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201100088 | - |
dc.identifier.wosid | 000294985200003 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Energy-Independent Intracellular Gene Delivery Mediated by Polymeric Biomimetics of Cell-Penetrating Peptides | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | amphiphiles | - |
dc.subject.keywordAuthor | biomimetics | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.subject.keywordAuthor | micelles | - |
dc.subject.keywordAuthor | polymers | - |
dc.subject.keywordPlus | FACIAL AMPHIPHILES | - |
dc.subject.keywordPlus | LOW-TEMPERATURE | - |
dc.subject.keywordPlus | DNA COMPLEXES | - |
dc.subject.keywordPlus | POLYETHYLENIMINE | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SYSTEMS | - |
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