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BielawskiChristopher W

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Isoelectronic Pt(II)- and Au(III)-N-heterocyclic carbene complexes: a structural and biological comparison

Author(s)
Rana, Bidyut KumarMishra, SnehasisSarkar, DeblinaMondal, Tapan KumarSeth, Saikat K.Bertolasi, ValerioDas Saha, KrishnaBielawski, Christopher W.Isab, Anvarhusein A.Dinda, Joydev
Issued Date
2018-07
DOI
10.1039/c8nj01562g
URI
https://scholarworks.unist.ac.kr/handle/201301/24436
Fulltext
http://pubs.rsc.org/en/Content/ArticleLanding/2018/NJ/C8NJ01562G#!divAbstract
Citation
NEW JOURNAL OF CHEMISTRY, v.42, no.13, pp.10704 - 10711
Abstract
To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C boolean AND N)(C)Cl][PF6] (2) and [Au(C boolean AND N)(C)Cl][PF6](2) (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(III)-NHC complex is more potent than its Pt analogue.
Publisher
ROYAL SOC CHEMISTRY
ISSN
1144-0546
Keyword
N-HETEROCYCLIC CARBENEDENSITY-FUNCTIONAL THEORYGOLD(III) COMPLEXESANTICANCER AGENTSANTITUMOR AGENTSGOLD CATALYSISCANCER-CELLSCHEMISTRYCYTOTOXICITYSILVER(I)

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