Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
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- Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
- Kim, Kyoung-Ran; Kim, Da-Rae; Lee, Taemin; Yhee, Ji Young; Kim, Byeong-Su; Kwon, Ick Chan; Ahn, Dae-Ro
- MULTIDRUG-RESISTANCE; DOXORUBICIN; THERAPY; CARRIER
- Issue Date
- ROYAL SOC CHEMISTRY
- CHEMICAL COMMUNICATIONS, v.49, no.20, pp.2010 - 2012
- A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
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