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김병수

Kim, Byeong-Su
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Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Author(s)
Kim, Kyoung-RanKim, Da-RaeLee, TaeminYhee, Ji YoungKim, Byeong-SuKwon, Ick ChanAhn, Dae-Ro
Issued Date
2013-03
DOI
10.1039/c3cc38693g
URI
https://scholarworks.unist.ac.kr/handle/201301/2435
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873636719
Citation
CHEMICAL COMMUNICATIONS, v.49, no.20, pp.2010 - 2012
Abstract
A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
Publisher
ROYAL SOC CHEMISTRY
ISSN
1359-7345

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