Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 611 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 603 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 41 | - |
dc.contributor.author | Park, Jung-Eun | - |
dc.contributor.author | Lee, Eun Ji | - |
dc.contributor.author | Kim, Jung Kwan | - |
dc.contributor.author | Song, Youngsup | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Kang, Min-Ji | - |
dc.date.accessioned | 2023-12-21T20:40:53Z | - |
dc.date.available | 2023-12-21T20:40:53Z | - |
dc.date.created | 2018-07-03 | - |
dc.date.issued | 2018-06 | - |
dc.description.abstract | Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the Drosophila flightless-I (fliI) gene in lipid metabolism. Drosophila fliI mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas fliI overexpression decreased triglyceride levels. These flies suffered from metabolic stress indicated by increased levels of trehalose in hemolymph and enhanced phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α). Moreover, upregulation of triglycerides via a knockdown of fliI was reversed by a knockdown of desat1 in the fat body of flies. These results indicate that fliI suppresses the expression of desat1, thereby inhibiting the development of obesity; fliI may, thus, serve as a novel therapeutic target in obesity and metabolic diseases. | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.41, no.6, pp.603 - 611 | - |
dc.identifier.doi | 10.14348/molcells.2018.0120 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-85056504242 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24261 | - |
dc.identifier.url | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2018.0120 | - |
dc.identifier.wosid | 000436198000012 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Flightless-I Controls Fat Storage in Drosophila | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.identifier.kciid | ART002385186 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | desaturase-1 | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | fat storage | - |
dc.subject.keywordAuthor | flightless-1 | - |
dc.subject.keywordAuthor | lipid metabolism | - |
dc.subject.keywordPlus | STEAROYL-COA DESATURASE-1 | - |
dc.subject.keywordPlus | LEUCINE-RICH REPEATS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INSULIN-RECEPTOR | - |
dc.subject.keywordPlus | GELSOLIN-LIKE | - |
dc.subject.keywordPlus | X-CHROMOSOME | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | METABOLISM | - |
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