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강주헌

Kang, Joo H.
Translational Multiscale Biofluidics Lab.
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Advection Flows-Enhanced Magnetic Separation for High-Throughput Bacteria Separation from Undiluted Whole Blood

Author(s)
Jung, Su HyunHahn, Young KiOh, SeinKwon, SeyongUm, EujinChoi, SungyoungKang, Joo H.
Issued Date
2018-08
DOI
10.1002/smll.201801731
URI
https://scholarworks.unist.ac.kr/handle/201301/24258
Fulltext
https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201801731
Citation
SMALL, v.14, no.34, pp.1801731
Abstract
A major challenge to scale up a microfluidic magnetic separator for extracorporeal blood cleansing applications is to overcome low magnetic drag velocity caused by viscous blood components interfering with magnetophoresis. Therefore, there is an unmet need to develop an effective method to position magnetic particles to the area of augmented magnetic flux density gradients while retaining clinically applicable throughput. Here, a magnetophoretic cell separation device, integrated with slanted ridge-arrays in a microfluidic channel, is reported. The slanted ridges patterned in the microfluidic channels generate spiral flows along the microfluidic channel. The cells bound with magnetic particles follow trajectories of the spiral streamlines and are repeatedly transferred in a transverse direction toward the area adjacent to a ferromagnetic nickel structure, where they are exposed to a highly augmented magnetic force of 7.68 mu N that is much greater than the force (0.35 pN) at the side of the channel furthest from the nickel structure. With this approach, 91.68% +/- 2.18% of Escherichia coli (E. coli) bound with magnetic nanoparticles are successfully separated from undiluted whole blood at a flow rate of 0.6 mL h(-1) in a single microfluidic channel, whereas only 23.98% +/- 6.59% of E. coli are depleted in the conventional microfluidic device.
Publisher
WILEY-V C H VERLAG GMBH
ISSN
1613-6810
Keyword (Author)
advection flowsbacteria separationmagnetic separationmagnetophoresismicrofluidics
Keyword
CELLSPURIFICATIONNANOPARTICLESDEVICENANOMAGNETS

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