BROWSE

Related Researcher

Author's Photo

Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Post-transcriptional Gene Expression, Neurodegeneration, Behavioral Genetics

ITEM VIEW & DOWNLOAD

Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster
Author
Sonn, Jun YoungLee, JongbinSung, Min KyungRi, HwajungChoi, Jung KyoonLim, ChunghunChoe, Joonho
Issue Date
2018-07
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.115, no.27, pp.7129 - 7134
Abstract
Sleep and metabolism are physiologically and behaviorally intertwined; however, the molecular basis for their interaction remains poorly understood. Here, we identified a serine metabolic pathway as a key mediator for starvation-induced sleep suppression. Transcriptome analyses revealed that enzymes involved in serine biosynthesis were induced upon starvation in Drosophila melanogaster brains. Genetic mutants of astray (aay), a fly homolog of the rate-limiting phosphoserine phosphatase in serine biosynthesis, displayed reduced starvation-induced sleep suppression. In contrast, a hypomorphic mutation in a serine/threonine-metabolizing enzyme, serine/threonine dehydratase (stdh), exaggerated starvation-induced sleep suppression. Analyses of double mutants indicated that aay and stdh act on the same genetic pathway to titrate serine levels in the head as well as to adjust starvation-induced sleep behaviors. RNA interference-mediated depletion of aay expression in neurons, using cholinergic Gal4 drivers, phenocopied aay mutants, while a nicotinic acetylcholine receptor antagonist selectively rescued the exaggerated starvation-induced sleep suppression in stdh mutants. Taken together, these data demonstrate that neural serine metabolism controls sleep during starvation, possibly via cholinergic signaling. We propose that animals have evolved a sleep-regulatory mechanism that reprograms amino acid metabolism for adaptive sleep behaviors in response to metabolic needs.
URI
https://scholarworks.unist.ac.kr/handle/201301/24235
URL
http://www.pnas.org/content/115/27/7129
DOI
10.1073/pnas.1719033115
ISSN
0027-8424
Appears in Collections:
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU