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DC Field | Value | Language |
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dc.citation.endPage | 2193 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2187 | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 38 | - |
dc.contributor.author | Vo, Vu T. A. | - |
dc.contributor.author | Choi, Jong-Whan | - |
dc.contributor.author | Phan, Ai N. H. | - |
dc.contributor.author | Hua, Tuyen N. M. | - |
dc.contributor.author | Kim, Min-Kyu | - |
dc.contributor.author | Kang, Byoung Heon | - |
dc.contributor.author | Jung, Soon-Hee | - |
dc.contributor.author | Yong, Suk-Joong | - |
dc.contributor.author | Jeong, Yangsik | - |
dc.date.accessioned | 2023-12-21T20:50:42Z | - |
dc.date.available | 2023-12-21T20:50:42Z | - |
dc.date.created | 2018-05-09 | - |
dc.date.issued | 2018-04 | - |
dc.description.abstract | Background/Aim: Cancer cells are distinct in terms of glutamine dependence. Here we investigated the different susceptibility of glutamine-independent and glutamine-dependent non-small cell lung cancer (NSCLC) to treatment with tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor gamitrinib-triphenylphosphonium (G-TPP). Materials and Methods: Cell viability and proliferation under glutamine deprivation and G-TPP treatment were determined by the MTT and colony-formation assays. Protein and mRNA expression were determined by western blot and quantitative polymerase chain reaction. Colorimetric-based assay was performed to check for glutamine synthetase (GS) activity. Results: NSCLC cells showed diverse adaptation under glutamine-depleted condition and were categorized into glutamine-independent and glutamine-dependent cells. Treatment with G-TPP particularly increased GS activity and induced cell death due to energy shortage indicated by phosphorylated AMP-activated protein kinase (AMPK) in glutamine-dependent cells. Conclusion: This finding provides better understanding of TRAP1-mediated glutamine metabolism through GS activity, and evidence that TRAP1 could be a promising therapeutic target for glutamine-addicted cancer. | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.38, no.4, pp.2187 - 2193 | - |
dc.identifier.doi | 10.21873/anticanres.12460 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.scopusid | 2-s2.0-85045206305 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24124 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/38/4/2187.abstract | - |
dc.identifier.wosid | 000428798000038 | - |
dc.language | 영어 | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.title | TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer Cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Glutamine metabolism | - |
dc.subject.keywordAuthor | TRAP1 | - |
dc.subject.keywordAuthor | gamitrinib-triphenylphosphonium | - |
dc.subject.keywordAuthor | glutamine synthetase | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordPlus | MITOCHONDRIAL HSP90 | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NETWORKS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | NSCLC | - |
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