Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 2345 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2337 | - |
dc.citation.title | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | - |
dc.citation.volume | 22 | - |
dc.contributor.author | Shin, Hanho | - |
dc.contributor.author | Han, Ji Hye | - |
dc.contributor.author | Yoon, Juhwan | - |
dc.contributor.author | Sim, Hyo Jung | - |
dc.contributor.author | Park, Tae Joo | - |
dc.contributor.author | Yang, Siyoung | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.contributor.author | Kulkarni, Rohit N. | - |
dc.contributor.author | Egan, Josephine M. | - |
dc.contributor.author | Kim, Wook | - |
dc.date.accessioned | 2023-12-21T20:52:16Z | - |
dc.date.available | 2023-12-21T20:52:16Z | - |
dc.date.created | 2018-05-04 | - |
dc.date.issued | 2018-04 | - |
dc.description.abstract | Cannabinoid 1 receptors (CB1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse beta-cell lines, human islets and CB1R-null (CB1R(-/-)) mice, we have now investigated the role of CB1Rs in modulating beta-cell function and glucose responsiveness. Synthetic CB1R agonists diminished GLP-1-mediated cAMP accumulation and insulin secretion as well as glucose-stimulated insulin secretion in mouse beta-cell lines and human islets. In addition, silencing CB1R in mouse cells resulted in an increased expression of pro-insulin, glucokinase (GCK) and glucose transporter 2 (GLUT2), but this increase was lost in cells lacking insulin receptor. Furthermore, CB1R(-/-) mice had increased pro-insulin, GCK and GLUT2 expression in cells. Our results suggest that CB1R signalling in pancreatic islets may be harnessed to improve beta-cell glucose responsiveness and preserve their function. Thus, our findings further support that blocking peripheral CB1Rs would be beneficial to beta-cell function in type 2 diabetes. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.22, no.4, pp.2337 - 2345 | - |
dc.identifier.doi | 10.1111/jcmm.13523 | - |
dc.identifier.issn | 1582-4934 | - |
dc.identifier.scopusid | 2-s2.0-85041912512 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24108 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.13523 | - |
dc.identifier.wosid | 000428418200028 | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.title | Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Cell Biology; Research & Experimental Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | beta-cell function | - |
dc.subject.keywordAuthor | cannabinoid 1 receptor | - |
dc.subject.keywordAuthor | glucokinase | - |
dc.subject.keywordAuthor | glucose transporter 2 | - |
dc.subject.keywordAuthor | insulin secretion | - |
dc.subject.keywordPlus | GLUCAGON-LIKE PEPTIDE-1 | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | CB1 RECEPTOR | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | CONCURRENT STIMULATION | - |
dc.subject.keywordPlus | ENDOCANNABINOID SYSTEM | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DIET | - |
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